Scores were tied in the morning foursomes with both teams taking two and a half points each. In the afternoon session it was still level going until the unbeaten Robert MacIntyre and Seamus Power went down 2&1 to the French-Italian combine of Victor Perez and Guido Migliozzi.
That gave Continental Europe a 3-2 win in the session and the overall score to eight and a half against six and a half points for GB&I.
Ten singles matches will be contested on Sunday.
The points provided by Molinari and Hojgaard thus helped Continental Europe stretch their overnight one-point lead to two over the Tommy Fleetwood-led opposition.
Contests continued to be tight on Saturday with no match finishing earlier than 16 holes and only one ending earlier on the first day.
Fleetwood played a key role in keeping his team’s deficit to a manageable level as he teamed with Tyrrell Hatton in the morning and then Jordan Smith in the afternoon to win both Foursomes.
Fleetwood/Hatton first beat Sepp Straka and Thomas Detry in the morning before Fleetwood/Smith got past the till-then unbeaten Thomas Pieters and Alex Noren 2&1 in the afternoon’s top match. The afternoon win was also a revenge of sorts for Fleetwood, who with Lowry, had been beaten by Pieters/Noren in the opening match of the week.
Molinari was all praise for Hojgaard: "I'm super, super impressed. It's been great to be out with him. Great attitude. I couldn't be happier.
“Win the first two games tomorrow and it’s all level. That’s what we’ve got to focus on. It’s been a very high standard so far. We’ve been behind all week and, if we can get off to a fast start in the singles and build momentum to get level with them and past them, that would be a really big deal to start with.”
On his own two wins, Fleetwood added, “There’s always individual pride when you get your own point and I’m happy about that. I loved playing with both Tyrrell and Jordan and was happy with how I performed with those guys.”
Also winning full points in both sessions were Perez and Migliozzi, who is eyeing a Ryder Cup spot in his home country, Italy, in September. The Perez-Migliozzi pairing put in a strong showing beating Irishmen Lowry and Power 3&2 in the morning and then Power and Scotsman MacIntyre in the afternoon.
Lowry, the highest world-ranked player at the Hero Cup at 20th, has lost all his matches.
Day 2 Results: Continental Europe 8.5 points, Great Britain/Ireland 6.5
Morning Foursomes: Cont Eur 2 ½ - GB&I 2 ½
Pieters/ Noren (Cont Eur) tied Ferguson/ Mansell
Straka/ Detry (Cont Eur) lost to Fleetwood/ Hatton 1 hole
Molinari/ Hojgaard (Cont Eur) bt Shinkwin/ Wallace 3&1
Rozner/ Meronk (Cont Eur) lost to Smith/ MacIntyre 1 hole
Perez/ Migliozzi (Cont Eur) bt Lowry/ Power 3&2
Afternoon Foursomes: Cont Eur 3 - GB & I 2
Pieters/ Noren (Cont Eur) lost to Fleetwood/ Smith (GB&I) 2&1
Molinari/ Hojgaard (:Cont Eur) bt Ferguson/ Mansell (GB&I) 2&1
Rozner/ Meronk (Cont Eur) lost to Shinkwin/ Wallace (GB&I) 2&1
Straka/ Detry (Cont Eur) bt Lowry/ Hatton (GB&I) 1 hole
Perez/ Migliozzi (Cont Eur) bt Power/ MacIntyre (GB&I) 2&1
Results - Day 1 fourballs (Europe lead 3-2)
Noren/Pieters (Cont Eur) bt Fleetwood/Lowry (GBI) 1-up
Rozner/Detry (Cont Eur) bt Hatton/Smith (GBI) 2-up
Shinkwin/Wallace (GBI) tied Migliozzi/Perez (Cont Eur)
Ferguson/Mansell (GBI) tied Molinari/Højgaard (Cont Eur)
Macintyre/Power (GBI) bt Meronk/Straka (Cont Eur) 4&3