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Coronavirus pandemic: Why it takes so long to make a vaccine

To create a coronavirus vaccine, scientists are creating DNA or RNA based vaccines that can be produced in the lab. This approach is faster and more reliable than traditional vaccine processing

twitter-logoBusinessToday.In | January 4, 2021 | Updated 16:28 IST
Coronavirus pandemic: Why it takes so long to make a vaccine
The actual time to create coronavirus vaccine in a traditional way would take at least 10 years

Coronavirus is spreading around the world, but there is still no drug that can kill the virus or vaccines that can protect against it. Research is happening at breakneck speed like never before to produce a vaccine for the deadly disease. The international community has said it would take at least a year to develop a vaccine for COVID-19.

According to Elissa Prichep, Precision Medicine Lead, World Economic Forum, the actual time to create coronavirus vaccine in a traditional way would take at least 10 years. However, with the advancement of technologies and international cooperation, the vaccine might be out between 12 and 18 months.

Prichep says creating a vaccine expeditiously, without appropriate testing, could put healthy people at risk. "One area of risk is vaccine enhancement, meaning the disease is more harmful to a vaccinated person," Prichep said.

Also read: Coronavirus India Live Updates: Delhi govt to do random testing in Delhi-NCR; country's active cases at 3,981

Traditionally, a vaccine for any disease is developed in four stages. In the first phase, a study is done on healthy people to evaluate the vaccine for safety and immune response. For COVID-19 trial, this would typically take one to two years. In the second stage, a study will be done on hundreds of random people. This will further evaluate the safety, assesses the efficacy and informs optimal dose and vaccine schedule. Typically, this would take two to three years. In the third phase, another randomised, placebo-controlled study of thousands of people to evaluate safety and efficacy. This will take two to four years to reach any conclusion. After this, a government body approves new vaccines reviews the trial data and other information in the licensing application. In the fourth phase, post-approval studies happen that monitor effectiveness in real-world conditions.

However, for COVID-19 vaccine, medical scientists are shaving several years from traditional vaccine development timelines. They are using the full genetic sequence of SARS-Cov2, the virus that causes COVID-19, to develop vaccines that will contain a small amount of genetic code. The human body cells will take up this genetic information and produce elements of the virus, not infecting the person but triggering the immune system to respond.

To create a coronavirus vaccine, scientists are creating DNA or RNA based vaccines that can be produced in the lab. This approach is faster and more reliable than traditional vaccine processing, which uses viruses grown in eggs or cell cultures. Gingko Bioworks has committed the capacity to manufacturing DNA or RNA based vaccines.

The innovative approach, applied for this vaccine,  could change how scientists develop future ones. The discovery of COVID-19 vaccine could make production more reliable and vaccines potentially more cost effective. The Coalition for Epidemic Preparedness Innovations ( CEPI) has made an urgent call for $2 billion in funding to support coronavirus's vaccine development, trials and enhanced manufacturing capacity.

Also read: Coronavirus: Japan PM Abe set to announce emergency, finalise $1 trillion stimulus package

Also read: Coronavirus impact: India withdraws export ban on 12 essential medicines

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