On the other hand, Sun Pharma, TCS, HCL Tech and HUL were the top gainers, rising up to 2.41 per cent.
According to traders, market turned choppy tracking weak cues from global markets and fresh selling of equities by foreign institutional investors (FIIs).
FIIs net sold shares worth Rs 501.11 crore on Tuesday, while domestic institutional investors (DIIs) purchased equities to the tune of Rs 269.22 crore, provisional data available with stock exchanges showed.
Global markets plunged Wednesday after the European Central Bank said a growth slump that could be caused by rising trade tensions is the biggest risk to financial stability in the eurozone.
Bourses elsewhere in Asia ended in the red, and those in Europe were also trading significantly lower in their early deals.
Meanwhile, the Indian rupee depreciated 18 paise to 69.87 against the US dollar.
Brent crude, the global benchmark, dropped 2.16 per cent to 67.19 per barrel.