On Monday, it had hit record highs as oil price fell and fund inflows picked up pace.
Wednesday's nearly 208-point drop is the biggest fall for Sensex since it lost 259.87 points on August 8, 2014.
On similar lines, the broader National Stock Exchange (NSE) index Nifty fell below the crucial 8,100 mark and closed 58.85 points (or 0.72 per cent) down at 8,094.10 on Wednesday. It had lost 20.95 points in the previous session.
Select buying in realty and power sector stocks cushioned losses, where as rupee falling to 1-month low and weakening global markets affected sentiments, said equity brokers.
Major losers that dragged down the indices include Hero MotoCorp, Infosys, ITC, Coal India, HDFC Ltd, HDFC Bank, BHEL, L&T, Maruti Suzuki, M&M, SBI, Tata Motors, TCS and Wipro.
Overall, 22 Sensex stocks declined while 8 ended up.
In addition, the rupee dipped below the 61-mark against the US dollar intra-day on concerns the US may raise interest rates sooner than investors had expected.
Sectorwise, the BSE Consumer Durable sector index suffered the most by falling 1.56 per cent, followed by Oil & Gas index 1.49 per cent, FMCG index by 1.48 per cent, IT index by 1.06 per cent and Capital Goods index by 0.99 per cent.
However, broader markets showed rise with BSE Mid-cap and Small-cap indices ending 0.08 per cent and 0.60 per cent up.
Meanwhile, Foreign Portfolio Investors (FPIs) bought shares worth a net Rs 479.40 crores on Wednesday, as per provisional data from the stock exchanges.